To evaluate the antiasthmatic and antianaphylactic activity of effect of aerial part of Leptadenia reticulata (Retz) on experimental models. The Unsaponifiable matter (LRUSM) from petroleum extarct, acetone (LRA), and methanol (LRM) extract of the aerial parts of Leptadenia reticulata (Retz) Wight and Arn. (Asclepiadaceae) were studied for Pharmacological evaluation. The Antiasthmatic and antianaphylactic activity of various extracts were studied on the active and passive anaphylaxis in rats induced by tripal antigen and horse serum, acetyl choline-induced bronchospasm in guinea pigs, anaphylactic shock induced in guinea pigs. Treatment with various extracts of Leptadenia reticulata (Retz) were showed a dose dependent (at 50, 100, mg/kg p.o.) beneficial effect on degranulation rate of actively and passively sensitized mesenteric mast cells of albino rats when challenged with antigen (horse serum). Leptadenia reticulata extract treatment for 7 days resulted in significant protection against acetylcholine aerosol-induced bronchospasm in guinea pigs. Treatment for 10 and 14 days, in guinea pigs respectively, offered marked protection against anaphylactic shock induced bronchospasm. Antiasthmatic and antianaphylactic activity aerial part of Leptadenia reticulata may be possibly due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine, suppression of IgE antibody production, due to compound like carbohydrate, glycosides, flavonoids, tannins, phytosterols like β-sitosterol, stigmasterol, in USM, Phenolic compounds in acetone(LRA) and methanolic extracts(LRM) of aerial part Leptadenia reticulata(Retz).
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